Cranial repair is a common surgical procedure to repair cranial defects caused by various reasons using certain cranial bone replacement materials to repair the defective area. Cranial repair surgery is widely used in neurosurgery, because cranial defect is a common disorder, cranial trauma may leave cranial defect, treatment of cerebral hemorrhage may require decompression of bone flap while removing hematoma, surgical treatment of brain tumor may also lead to cranial defect, and cranial lesion itself, all of which require cranial repair. The more important point of cranial repair surgery is the selection of repair material. In the past, titanium mesh was the widely used material for skull repair in most hospitals for a long period of time, but it was found that there are certain problems in clinical use, such as rejection, which is not high, but can be very troublesome if it happens. The rejection phenomenon is mainly related to the individual’s constitution, mainly related to the characteristics of the immune system, that is, the compatibility of human tissues with the titanium mesh metal material. Titanium mesh material tissue compatibility is still relatively high, most people are fine, but there are still a small number of people with special constitution and strong sensitivity of the immune system, may be implanted in the human body as a foreign body titanium mesh material, rejection reaction, titanium mesh metal material stability is very strong, rejection will not cause damage to the titanium mesh, the result of injury can only be the human body itself, mainly manifested as scalp tissue damage, or even cause material exposure . Of course, in addition to the phenomenon of rejection, titanium mesh material may also have other problems, such as post-operative infection, wear and tear of the scalp, which can also cause material exposure, as well as affect the CT magnetic resonance examination, strong thermal conductivity, sensitivity to external hot and cold environment, discomfort, poor shaping effect, etc.. Therefore, the use of titanium mesh for skull repair is not very recommended at present. In recent years, a new type of special polymer material has emerged – polyetheretherketone PEEK, which is highly histocompatible and has not been found to be rejection cases. Other properties are also excellent, and can well overcome the above-mentioned problems that may arise from titanium mesh materials, gradually becoming a new trend in cranial repair materials.