Colds that have been bad for a long time are not necessarily a harbinger of any disease, but one of the symptoms that has been bad may suggest some pathology. When a cold stays bad, first of all, it should be clear whether it has undergone regular treatment, as well as adequate rest and water intake; secondly, it should be clear whether there is any immunocompromise or defect; and lastly, it should be considered whether there is any secondary infection, such as sinusitis, otitis media, and so on. Common symptoms of colds include cough, nasal congestion, runny nose and headache. If some of these symptoms are not relieved after treatment, the presence of other pathologies should be considered. For example, headache can be seen in sinusitis, otitis media, migraine, intracranial infections, etc. Cough can be seen in lung infections, tumors, rhinitis and sinusitis. Cold and flu is not good for a long time, need to be further examined, by the physician comprehensive judgment.