Generalized soreness and weakness muscle soreness may be caused by physiological factors overwork, but also rheumatoid arthritis, dermatomyositis and other pathological factors. 1. Physiological factors: strenuous exercise after a long period of inactivity will lead to overexertion of the body, anaerobic metabolic reactions, resulting in a large amount of lactic acid accumulation in the muscles, ligaments and other soft tissues, which in turn will cause generalized soreness and weakness, muscle aches and pains. 2. Pathological factors: rheumatoid arthritis often causes joints to suffer from aggression, resulting in inflammation of the joint tissues, thus affecting the muscles, ligaments and other tissues, so as to produce the symptoms of generalized aching and weakness. The body suffers from viral or bacterial infections will lead to disorders in the body’s immune system, which can easily cause dermatomyositis, leading to the symptoms of generalized muscle aches and pains. In conclusion, there are many reasons that lead to generalized weakness and muscle pain, in order to relieve the symptoms as soon as possible, it is recommended to go to the hospital for standardized examination to clarify the cause of the disease, and actively cooperate with the treatment.