Serpentine sores, or shingles, can be relieved by the use of medications or physical methods when the itchiness of postherpes zoster is unbearable. Herpes zoster is an acute infectious skin disease caused by varicella zoster virus, typically manifested as clusters of painful blisters distributed in bands. When its sequelae appear strange and itchy, it is a neurosensory abnormality. Acetaminophen, tramadol, gabapentin, pregabalin and other medications can be added to the treatment, thus providing a therapeutic effect of relieving itching and pain. At the same time, neurotrophic drugs such as methylcobalamin, vitamin B1, vitamin B12 can also be used to nourish the nerves and relieve itching. Localized irradiation such as ultraviolet and infrared rays can also provide relief. The use of drugs should all be under the guidance of medical professionals to avoid adverse reactions.