Dagliflozin can be used in combination with metformin of pioglitazone, but it is necessary to pay attention to the relevant contraindications, and should be used in accordance with medical advice. Dagliflozin can be combined with metformin and pioglitazone in the treatment of type 2 diabetes mellitus, which can have cardiovascular benefits, such as reducing cardiac load and improving cardiac function. However, it is important to note that you need to drink plenty of water when using the combination in order to lower the urine glucose concentration. Dagliflozin is not recommended for people with urinary retention and recurrent urinary tract infections due to its mechanism of eliminating large amounts of glucose from the urine, which carries a risk of urogenital infection; in addition, it is contraindicated for people who are allergic to the drug components, have severe renal impairment insufficiency, or who require dialysis. Pioglitazone metformin is contraindicated in patients with type 1 diabetes mellitus, diabetic ketoacidosis, severe hepatic and renal insufficiency. Dagliflozin and pioglitazone metformin must be used as directed by a physician.