Bone marrow exchange is harmless to a person, the so-called bone marrow exchange is the common name of the people, clinically known as bone marrow donation or hematopoietic stem cell donation. The process of donation is harmless to the donor. First of all, for the donor, the bone marrow will be stimulated to release stem cells into the peripheral blood, and in the short term, there may be some very uncomfortable symptoms, such as pain in the body or a decrease in resistance, but after the donation, such symptoms will gradually disappear. The donor’s future life and bodily functions will not be affected by the donation. This type of donation has been practiced worldwide for more than 50 years, and no adverse complications have been reported. For the recipient, this treatment is the only effective and curative treatment that has failed all other treatments. If the patient is suffering from a very serious blood-related or autoimmune-related disease and other treatments have failed, HSCT may be the only treatment that can make a fundamental difference. Therefore, it is recommended that once the recipient has been matched, the patient undergoes this treatment, no matter how risky it may be. This is because at this point in time this type of treatment is the only treatment that can save the patient’s life and ensure that he or she is able to live a normal life in the future.