Women at the age of 50 can still have normal conjugal life, and it is good for physical and mental health, and it can also prevent endocrine disruption. Women at the age of 50 are in menopause and perimenopause, the level of estrogen in the body will gradually decline, and may show some symptoms of menopause, such as insomnia, palpitations, menstrual disorders and low libido. Normal couple life can effectively relieve these symptoms and is good for women’s physical and mental health. In menopause and menopausal women, the ovary function starts to degenerate gradually, and the secretion of estrogen and progesterone starts to decrease gradually, resulting in endocrine disorders. Appropriate couple life can effectively promote the secretion of estrogen in the body, stabilize the hormone level and prevent endocrine disruption. If women under the age of 50 feel unwell, it is recommended that they go to the hospital in time and follow the doctor’s instructions for treatment.