Lupus erythematosus nephritis type IV, also known as diffuse proliferative lupus nephritis, has become more severe. Active or inactive lesions with a diffuse (equal to or greater than 50% of glomeruli involved) segmental or globular distribution. Both intracapillary or extracapillary proliferative lesions may be present, with diffuse subendothelial complex deposition, with or without proliferative lesions of the mesangium. Lupus erythematosus nephritis type 4 may present proteinuria, hematuria, edema, joint pain, fever, facial erythema and other related symptoms, and in severe cases, patients may have elevated blood pressure and blood creatinine. Lupus erythematosus nephritis type 4 is very harmful to kidneys, if not treated actively, kidney function may deteriorate rapidly, or even develop into chronic renal failure. Lupus nephritis type 4 patients should go to the hospital in time for treatment under the guidance of professional doctors.