Patients with orbital venous reflux disorder have a good bilateral onset with protruding eyeballs, typical eyelid signs such as receding eyelids and late fall of the upper eyelids, and restrictive eye movement disorders. Even with normal thyroid function, a diagnosis of thyroid-associated ophthalmopathy can still be made with close testing of thyroid function if the above-mentioned signs are present. In the minority of patients with thyroid-related ophthalmopathy who present with ptosis, they should be examined for the combination of myasthenia gravis, both of which are immune disorders that can occur concomitantly and for which glucocorticoids and immunosuppressive drugs are effective. What are the prevention methods for thyroid-related eye disease? 1, actively adjust thyroid hormone levels to maintain them in the normal range, and avoid sudden reduction or increase of medication. 2. Avoid spicy and irritating foods, prevent eye strain, wear sunglasses when exposed to bright light, and avoid emotional stress. The head should be elevated during sleep, and those with incomplete lid closure should apply eye ointment or wet room protection. 3. Quit smoking. Patients who smoke are more likely to have progressive and more serious orbital disease. Too much physical and mental stress can cause hyperthyroidism. Diabetes plays a role in promoting thyroid-related eye disease. Other immune diseases including pernicious anemia and vitiligo can also be combined with thyroid disease. Radiotherapy to the neck in patients with non-thyroidal diseases, such as thyroid cancer and Hodgson’s disease, may induce thyroid-related ophthalmopathy. 4. There is also a relationship between the treatment modality of hyperthyroidism and the occurrence and severity of orbitopathy. Patients who implement iodine radiotherapy for hyperthyroidism have a higher probability of developing severe orbital disease and further progression of the disease. Early and complete control of hyperthyroidism is essential for the treatment of orbital disease, and similarly, early detection and control of secondary hypothyroidism is beneficial for the treatment of orbital disease. Thyroid suppressant medications may reduce the incidence and severity of orbital disease.