Non-invasive DNA prenatal testing vs. Down’s syndrome screening, many pregnant mothers choose to spend more money on non-invasive DNA testing. In reality, it is not as complicated as patients think. Ordinary Down’s syndrome screening is calculated through ultrasound imaging, which is a statistical point of view, so the accuracy rate is about 60%. Non-invasive DNA prenatal testing, on the other hand, is the result of a test performed by collecting the pregnant mother’s venous blood, and therefore has an accuracy rate of 95%. The test results are more accurate and reliable! If you don’t know enough about why non-invasive DNA is expensive, read on! What is a non-invasive DNA prenatal test? Non-invasive DNA prenatal testing is also known as non-invasive fetal chromosome aneuploidy testing. It is performed by collecting the pregnant mother’s venous blood, sequencing the free DNA fragments (including fetal free DNA fragments) in the mother’s peripheral plasma using next-generation DNA sequencing technology, and then performing bioinformatics analysis on the test results to obtain the fetal genetic information. The test is available to pregnant mothers with either singleton, twin or IVF pregnancies; the test results are not affected by maternal age, race or the presence of pregnancy-related diseases such as diabetes. Why should I get a non-invasive DNA test? This is a question that many pregnant mothers ask. In fact, the main reason for doing this test is to reduce unnecessary punctures for some pregnant women, which can reduce miscarriages due to punctures; secondly, doing non-invasive DNA testing can reduce pregnant mothers’ worries and anxieties; for our medical staff, through non-invasive DNA testing, we can reduce missed diagnoses and avoid medical disputes. Who are suitable for non-invasive DNA testing? Pregnant women over 35 years old with advanced maternal age; Pregnant women with increased fetal NT or other anatomical abnormalities on ultrasound; Pregnant women with high risk or altered values of single indicators on Down screening; Pregnant women who are not suitable for invasive prenatal diagnosis, such as: low amniotic fluid, placenta previa, virus carriers, RH blood group negative, history of miscarriage, pre-eclampsia or precious children; Pregnant women who have failed amniocentesis cell culture and are unwilling to undergo it again or cannot undergo it again Pregnant women with invasive prenatal diagnosis. What is the best time for non-invasive DNA testing? The general timing of the test is between the 12th and 24th week of pregnancy. Does every pregnant mother need to have a non-invasive DNA test? Usually pregnant mothers who have done their serological Down screening and NT screening are recommended to have a non-invasive prenatal genetic test first if the results are high risk. This is because the accuracy rate of traditional screening is around 60%, which means that there is a problem of false positives and false negatives. If the result of the non-invasive prenatal genetic test is still high risk, then it is time to have a puncture for prenatal diagnosis; if the result of the non-invasive prenatal genetic test is low risk, there is no need to have a puncture! For high-risk pregnant women and those who are financially well-off, a non-invasive prenatal genetic test can be done for more peace of mind.