The liver is the largest organ in the body’s internal organs and is normally located in the abdomen of the body, below the diaphragm and above the stomach. The falciform ligament divides the liver into left and right parts, the left and right livers, with the right lobe being large and thick and the left lobe being small and thin. The underside of the liver is concave, adjacent to the abdominal organs. Most of the liver is located in the right quarter of the ribs and the epigastrium, and a small portion is located in the left quarter of the ribs. The liver is mostly covered by the costal arches and is only exposed for about 3 centimeters or so between the left and right costal arches in the upper part of the abdomen, against the anterior abdominal wall. The position of the liver often changes with respiration, usually rising and falling up to 2-3 cm during calm breathing, falling slightly when standing and inspiratory, and rising slightly when supine and inspiratory. In adults, if the liver is palpable under the right costal arch, it is usually pathologically enlarged; in young children, the lower edge of the liver is lower and may be exposed under the right rib cage. In addition, in a very small number of congenital variants, the anatomical position of the organs is completely reversed, with a left-sided liver. The liver is the largest digestive gland in the human digestive system, with the function of secreting bile to help digestion; the liver is also an important metabolic organ in the human body, participating in the synthesis and metabolism of sugar, protein and fat, and has the function of detoxification. Liver is also a very fragile organ, viruses, alcohol, drugs, poisons, etc. can cause liver damage, laboratory tests will show elevated aminotransferases and bilirubin, and severe liver damage will lead to a drop in albumin and abnormal coagulation function. It should be noted that visceral nerve localization is relatively vague, not like the body surface nerves can clearly locate the site of stimulation, liver lesion pain, usually diffuse, unclear localization of dull pain, the range is not fixed, and many liver diseases early only see changes in indicators, no abnormal sensations, so clinically it is difficult to specific areas of discomfort to determine the presence of liver disease, so the discomfort in the liver area is not a reliable basis for diagnosis, suspicion of liver disease, and the liver area of discomfort. Therefore, the discomfort in the liver area is not a reliable diagnostic basis, and patients who suspect liver disease should consult a doctor in time for a systematic examination and a clear diagnosis in order to guide the treatment.