The formation of liver nodules is caused by the proliferation of fibrous tissue in the liver due to various factors, and is the result of hepatocellular lesions, which usually result from the proliferation of fibrous tissue and the destruction of normal liver tissue structure after hepatocyte damage and necrosis. Liver nodules are often caused by liver diseases such as hepatic nodular regenerative hyperplasia, hepatic partial nodular lesions, hepatic adenoma, and cirrhosis. Hepatic nodular regenerative hyperplasia is a rare disease in which small hepatocellular nodules are diffusely distributed throughout the liver with no fibrous tissue surrounding the nodules. Nodular lesions in parts of the liver occur mainly around the hilum and may cause portal hypertension, while the rest of the liver tissue is normal or has atrophy and liver function is normal. Hepatic adenoma is also one of the causes of nodules on the liver. It is a relatively rare benign neoplastic disease of the liver, the cause of which may be related to the application of birth control pills. Cirrhosis is the most common factor causing nodules on the liver. Patients with cirrhosis will have abnormal proliferation of liver fiber tissue due to the death and atrophy of liver cells, and therefore will have nodules on the liver. The nodules on the liver should be taken seriously and further examination is needed to identify the specific cause of the disease and then timely treatment to prevent the nodules on the liver from becoming malignant and turning into liver cancer.