Fever of 38.6 degrees can follow the doctor’s instructions oral antipyretic drugs, at the same time can do physical cooling, such as disposal of persistent high fever, you should immediately go to the hospital for blood tests and other tests to clarify the cause of the disease for targeted treatment. When the fever is 38.6 degrees, you can take oral antipyretic medicines, such as ibuprofen, under the guidance of the doctor. You can use warm water and towel to wipe your body several times to achieve physical cooling effect. Drink plenty of water, rest more, ensure sufficient sleep, eat a light diet, avoid spicy stimulation. At the same time, you should actively search for the cause of fever and treat the cause. If the fever is caused by bacterial infection, amoxicillin, roxithromycin and other drugs can be given. Tumor fever is also known as tumor-associated fever, which should be actively treated with surgery, radiotherapy and other treatments. Patients with rheumatic immune disease who have fever need to go to the hospital to ask the doctor for diagnosis and treatment, and do relevant laboratory tests, including blood routine, urine routine, liver function and so on. Fever in symptomatic treatment at the same time, should actively carry out the etiological treatment, drugs need to follow the doctor’s instructions for rational application.