Neonates of HBsAg-positive mothers should be given hepatitis B immunoglobulin (HBIG) as early as possible within 24 h after birth (preferably 12 h after birth) at a dose of ≥100 IU, along with 10 μg of recombinant yeast or 20 μg of Chinese hamster oocyte (CHO) Hepatitis B vaccine at different sites, and the second and third doses of Hepatitis B vaccine at 1 month and 6 months, respectively. vaccine at 1 month and 6 months of age, which significantly improves the effectiveness of interruption of mother-to-child transmission. Alternatively, one injection of HBIG can be given within 12 h of birth, followed by a second injection of HBIG one month later, and a single injection of 10 μg of recombinant yeast or 20 μg of CHO hepatitis B vaccine at different sites, with second and third injections of hepatitis B vaccine at intervals of 1 and 6 months, respectively. Newborns could receive breastfeeding from HBsAg-positive mothers after receiving HBIG and hepatitis B vaccine within 12 h of birth.