There are many reasons for waking up in the middle of the night coughing, such as environmental discomfort, positional influence, trachea and bronchitis, cough variant asthma, pneumonia, etc.. 1. Environmental discomfort: If the room is too dry, it will make the throat dry, itchy when breathing, and then coughing, and even waking up in the middle of the night cough, generally after waking up can be relieved by drinking water and other ways to ease the discomfort of the throat. 2. The influence of position: for example, when lying down on the upper respiratory tract secretions, due to the influence of position, will accidentally enter the lower respiratory tract, and then appear in the middle of the night to wake up coughing phenomenon. 3. Tracheitis and bronchitis: due to infection, smoking, climate change and other internal and external factors, can be manifested as coughing, phlegm, runny and other symptoms during sleep, coughing will wake up when coughing. 4. Cough variant asthma: affected by environmental and genetic factors, the disease can make patients have dry cough, chest tightness, paroxysmal dyspnea, etc., and it is easy to wake up from coughing in the middle of the night. 5. Pneumonia: If the patient’s lungs are infected by pathogenic microorganisms, coughing, shortness of breath, shortness of breath and other symptoms, and in severe cases, can wake up coughing. 6. Other: the situation of waking up in the middle of the night cough can also be seen in heart failure, gastroesophageal reflux, upper airway cough syndrome and other diseases of the patient, the middle of the night cough. Coughing in the middle of the night for a long time, you should go to the hospital in time, after a clear cause for targeted treatment.