The difference between Trimetazidine Hydrochloride Tablets and Nicorandil Tablets includes different mechanisms of action, different indications, different contraindications, and so on. 1. Mechanism of action: trimetazidine hydrochloride tablets protect the energy metabolism of cells in hypoxia or ischemia, prevent the decline of intracellular ATP level, ensure the normal function of the ion pump to maintain the stability of the intracellular environment; Nicorandil has the effect of preventing intracellular calcium ions from leaving the cell, increasing the permeability of the cell membrane to potassium ions, dilating coronary blood vessels, and inhibiting coronary artery spasm. 2. Indications: Trimetazidine hydrochloride tablets are used for symptomatic treatment of adult patients with stable angina pectoris who are poorly controlled or intolerable to first-line anti-angina treatment; Nicorandil tablets are used for the treatment of coronary heart disease and angina pectoris. 3. Contraindications: Trimetazidine hydrochloride tablets are contraindicated in those who are allergic to trimetazidine hydrochloride or any of the excipients, Parkinson’s disease, Parkinson’s syndrome, tremor, restless legs syndrome, and other related movement disorders, severe renal impairment is prohibited, athletes should be cautious; Nicorandil tablets are contraindicated in patients with glaucoma, and should be used with caution in pregnant women and breastfeeding women. The above content is for reference only, patients who need to use trimetazidine hydrochloride tablets and nicorandil tablets, it is recommended to go to the regular hospital for a clear diagnosis, strictly comply with the doctor’s instructions to use the drug, not blindly self-medication, in order to avoid adverse reactions.