Local venous pressure pain is a symptom of thrombophlebitis, which is a common clinical condition. It can develop in both men and women, and is more common in young adults. The clinical features are: sudden onset of redness, burning, pain or pressure along the superficial veins, and the appearance of striae or hard nodules. After the acute phase, the cords become hard and the local skin becomes pigmented. So, which diseases should be differential diagnosis for local venous tenderness? The following is a brief introduction: 1, primary iliofemoral vein thrombosis: thrombosis is located in the iliofemoral vein, the incidence is lower than that of calf deep vein thrombosis, and it is more common on the left side, 1-8 times that of the right side, and the cause is the compression of the left common iliac vein anatomically by the right common iliac artery and the structural abnormality in the lumen, and in 1965 Cocket et al. analyzed such lesions and put forward for the first time the The concept of “iliac vein compression syndrome” was first introduced by Cocket et al. The clinical symptoms of this disease are obvious and have an abrupt onset. There is pain and tenderness, and the thrombus stimulates an inflammatory response within the iliofemoral vein, which can produce local pain and tenderness. In some patients, a thrombus-filled stripe in the femoral vein can often be found in the femoral triangle. Swelling is often evident, and the circumference of the thigh or calf usually differs from the healthy side by several centimeters. In some cases, compensatory superficial varicose veins may be seen. The body temperature is elevated but mostly does not exceed 38.5℃. 2, secondary iliofemoral vein thrombosis: also known as mixed deep vein thrombosis, the thrombus originates from the calf muscle plexus and spreads upward, involving the iliofemoral vein. This disease has the following clinical characteristics: the mode of onset is mostly insidious. The symptoms are mild at the beginning and do not appear until the iliofemoral vein is involved, so the actual lesion period is longer than the symptomatic period. Nutritional changes in the foot and shoe area. 3.Femoral cyanosis: The most serious type, either primary or secondary iliofemoral vein thrombosis, is formed when the entire venous system of the affected limb, including potential side branches, is almost completely obstructed, while causing strong arterial spasm. The typical symptoms are widespread and obvious swelling of the affected limb, tense, shiny and cyanotic skin, which may be accompanied by blistering, and a marked decrease in skin temperature of the affected limb and a weakening of the dorsal foot and posterior tibial artery.