During the clinical use of local anesthetic drugs, some patients may develop drug allergy, such as generalized urticaria, and patients with severe allergy may develop headache, skin tissue edema and anaphylaxis in severe cases. Once the allergy occurs, the anesthetic drugs need to be stopped urgently and anti-allergy treatment should be carried out. In addition, in clinical practice, in order to avoid allergy to local anesthetic drugs, strict limits should be set, attention should be paid to backdrawing before injection, and an appropriate amount of epinephrine can be added to slow down the absorption when there are no contraindications.