Gram-positive cocci are a type of bacteria, including staphylococcus and streptococcus are gram-positive cocci, so, gram-positive cocci infections are bacterial infections, the treatment is to use sensitive antibiotics, the treatment is relatively easy. Gram-positive cocci infections often cause purulent inflammation, so they are also known as pyogenic cocci. These bacteria can be found widely in nature and can be found in the air, water, soil; skin, intestinal mucosa, gastrointestinal tract and other parts of humans and livestock. For the treatment of gram-positive cocci, penicillin is the antibiotic of choice; however, penicillin allergy can be treated with macrolide antibiotics, including erythromycin and azithromycin. Therefore, Gram-positive cocci are not particularly difficult to treat once diagnosed.