Impotence is known as erectile dysfunction in medicine. Benzocaine is not a commonly used therapeutic drug for this condition, and its private use may lead to adverse reactions, drug resistance, drug overdose and other harmful effects. First of all, it needs to be clear that benzocaine is generally used as a local anesthetic for the treatment of premature ejaculation and does not have a therapeutic effect on male erectile dysfunction. Therefore, erectile dysfunction does not meet the indications of benzocaine, unauthorized use of the drug may produce many risks. 1. Adverse reactions: the use of benzocaine may occur in the process of local irritation (such as skin burning), allergic reactions (such as rash, itching), methemoglobinemia (such as skin and mucous membrane bruising, shortness of breath) and other adverse reactions. 2. Drug resistance: mostly seen in long-term large-scale use of benzocaine, drug resistance is caused by the body’s sensitivity to the drug is reduced. 3. Overdose: If overdose occurs, patients may experience visual abnormalities, confusion, dizziness, drowsiness, numbness, abnormal heart rate, dyspnea and other toxic reactions. It should also be noted that benzocaine is contraindicated in people who are allergic to local anesthetic drugs. Therefore, the diagnosis of erectile dysfunction, must be under the guidance of the doctor for the selection of therapeutic drugs and standardized use, do not blindly self-medication, so as not to cause adverse consequences.