Four Spirits Pill is formulated with Schisandra chinensis, nutmeg, tonic acid, Wu Zhu and jujube. The efficacy of Si Shen Wan is to warm the kidneys, warm the spleen, consolidate astringency and stop diarrhea, and is mainly used in treating Wu Wei Diarrhea (diarrhea before dawn), inability to think of food, inability to eat and digest, deficiency and coldness of the spleen and kidneys, or abdominal pain and coldness of the limbs, and fatigue of the spirit (mental fatigue and physical weakness). In the formula of Si Shen Wan, tonic bone resin is used to tonify the fire of the vital gate, which is the main medicine; nutmeg astringes the intestines and stops diarrhea (relieves diarrhea by enhancing the astringency of the intestinal tract), which, together with tonic bone resin, warms the kidneys and spleens, and is therefore the ministerial medicine; schizandra consolidates the kidneys and strengthens the qi, and wu wu jiao warms the middle Jiao, which is the adjuvant; jujubes replenishes the spleen and nourishes the stomach, while ginger warms the middle Jiao to dissipate the cold, which is the enabling medicine. Adverse effects of Si Shen Wan are not known. Contraindications are not clear. If you need to use the drug is recommended to be used under the guidance of a traditional Chinese medicine practitioner to identify the evidence, not self-medication, so as not to cause adverse effects.