A patient once asked why the old man’s diabetic gangrene was never cured. I asked how it was treated, and he said it was just hanging water every day to reduce inflammation and using insulin to lower blood sugar, saying that he would wait until the blood sugar came down and then clean the wound to see. I learned further that the patient had wet gangrene, and here we found the cause of the disease. First of all, wet gangrene is something that needs to be cleared as soon as possible, not until the blood sugar comes down. Unlike dry, blackened and dried gangrene, wet gangrene does not exist or there are less severe arterial vascular lesions in the lower extremities, which are often predominantly infected and purulent ulcers occur. The infection needs to be controlled as soon as possible for this condition to work, and one of the reasons why doctors are treating it more and more severely is because they are not doing debridement of the wound in a timely manner. Unlike wet wounds, which need to be debrided as soon as possible, dry gangrene needs to be debrided only after circulation to the lower extremities has been improved. You may say that you need to wait for the blood sugar to come down before you can clear it, and there is nothing wrong with that idea, but for diabetic foot infected wounds, you need to consider the priorities, what needs to be done first and completed first, and distinguish between the major and minor conflicts. To know the infection can not be controlled, but also on the blood glucose stress response, blood glucose will be further out of control, so that the treatment into a strange circle. Some patients treated in our hospital have high blood sugar during treatment. On the one hand, we have to consider the patient’s own situation, how islet function, and the control standard is definitely different for young patients and older patients. On the other hand, as long as the blood glucose does not have acute complications, it can be slowly regulated during the debridement, but the most important thing is to control the infection. Why do we have to clean the wound to control the infection? Can’t we use antibiotics? Of course not! Because the infected wound actually has a large amount of inflammatory necrotic tissue, which is exactly the breeding ground for germs and contains a large number of germs. Why are some patients unable to control the infection despite the large amount of antibiotics used during treatment? It is because of the large load of germs, eliminating part of it, and another part up, how can not be eliminated. This analysis shows one of the reasons why this patient has not been able to heal, but of course there are many aspects that affect wound healing, at least this is the main one. Therefore, doctors must develop a targeted treatment plan according to the characteristics of different wounds, so as not to delay the best time for treatment.