You should not drink alcohol during the rabies vaccination. If you drink alcohol, it can cause two things. One is to cause adverse reactions or increased adverse reactions to the rabies vaccine, and the other is to cause the rabies vaccine to fail to prevent rabies attacks. The reason for this is that the rabies vaccine is a foreign antigen, and if alcohol is consumed, the body’s alcohol concentration increases and the vaccine at the injection site may be affected by the alcohol, resulting in denaturation of the antigen. Once denatured, because it is foreign, it is likely to lead to abnormal immune system response and even allergy, increasing adverse reactions, manifested as local redness, swelling, and even fever or allergic reactions. It takes time for the rabies virus to enter the peripheral nerves in a local wound. Drinking alcohol accelerates blood circulation, potentially speeding up this process, and it is possible that the rabies vaccine may not be ready to work when the rabies attack occurs.