Lipitis patients with tacrolimus still peeling skin is caused by the lack of reasonable use of medication, should be under the guidance of a doctor’s treatment, including drug treatment, general treatment. Tacrolimus capsules are used for liver or kidney transplant recipients, tacrolimus extended-release capsules are used to prevent graft rejection after kidney transplantation, and tacrolimus ointment is used for atopic dermatitis patients. Tacrolimus cannot treat lipitis. If patients use the drug by themselves, not only can it not be effective, but it may also have many kinds of adverse reactions, such as vision abnormalities, abscesses and so on. Patients should standardize the treatment under the guidance of the doctor, you can apply topical antibiotic ointment such as gentamycin, tretinoin or hormone ointment for patients with desquamative labiitis. If necessary, you can also take vitamin A orally to reduce the flaking of the mucous membrane of the lips. Life also needs to change the bad habits such as lip biting and lip licking, quit smoking and drinking in time, avoid spicy and stimulating food to avoid irritation. Lipitis patients should go to the local regular hospital, follow the doctor’s instructions for medication, avoid self-medication.