When to take aspirin depends on the patient’s specific situation and cannot be generalized. Aspirin is an anti-platelet aggregation drug, which is currently the main clinical treatment for cardiovascular disease and can be used as a routine treatment to prevent recurrence of heart and brain stroke. Aspirin has certain irritating effects on the gastrointestinal tract and may cause adverse reactions such as stomach discomfort, nausea, vomiting, acid reflux, and even ulcers or bleeding. If the patient has no stomach discomfort and the gastrointestinal tract is functioning well, it is recommended to take aspirin in the morning on an empty stomach. This is because taking aspirin in the state of stomach emptying can relatively reduce its residence time in the stomach and reduce the irritation and damage to the stomach. If a patient has gastritis or other stomach problems, it is recommended to take aspirin after a meal. Patients should also note that alcohol consumption, coagulation disorders, patients with ulcers or combined bleeding, and pregnant women are not allowed to use this drug, and it is recommended to use it under the guidance of a doctor.