The correct generic name for Nicorandil Sigmoid is Nicorandil and Sigmoid is its trade name, which acts as an antimyocardial ischemia and improves microcirculation in patients. Nicorandil is a calcium antagonist and potassium channel opener, which can dilate coronary blood vessels, increase coronary blood flow persistently, and inhibit coronary artery spasm; at the same time, Nicorandil can also produce similar effects as nitrate drugs, which have strong dilatation effects on large coronary arteries and increase coronary artery blood flow. Therefore, Nicorandil can improve myocardial ischemia through a dual mechanism of action. Recent studies have found that Nicorandil can reduce myocardial damage from ischemia/reperfusion, decrease myocardial edema and infarct size, and also inhibit platelet aggregation to prevent thrombosis. Nicorandil, as one of the preferred therapeutic agents for antimyocardial ischemia, improves microcirculation in patients’ coronary arteries. After administration, patients may experience adverse reactions such as headache, dizziness, tinnitus, insomnia, abdominal pain, diarrhea, dyspepsia, loss of appetite, nausea, vomiting, constipation, palpitations, fatigue, facial flushing, and swelling of the lower extremities. It should be noted that this drug is contraindicated in patients who are allergic to this product, patients with glaucoma, and patients with severe liver and kidney diseases. The application of this drug should also be prohibited when there is a change in the nature of the drug. Due to the different medical conditions of patients, it is still necessary to follow the instructions of the doctor on how to use the drug.