Monkeypox disease is mainly infected with monkeypox virus caused by a zoonotic infectious diseases. 1. Monkeypox disease is similar to smallpox, but not as heavy as smallpox, the incubation period is generally 7 to 14 days, the longest can be up to 21 days, the people who have been vaccinated against smallpox can have a certain degree of immunity to it. 2. Common clinical manifestations are: headache, fever, swollen lymph nodes, rash, etc. Rash acne process for papules, blisters, pustules, and finally scab off, accompanied by pain. 3. Monkeypox is a self-limiting disease, after the onset of the process is over, usually 2 to 4 weeks after the gradual recovery, but if the physical condition is not good or serious complications may also have the risk of death. If symptoms similar to those described above occur, seek medical attention, isolation and treatment after diagnosis.