Multiple subpleural nodules can usually be treated with medication and surgery, and medication should be used according to the doctor’s instructions. Inflammation, lung cancer, pleural malignant tumor and other diseases are often considered. 1. Inflammation: the edges of nodules are blurred, the size is different, patients may or may not have symptoms, anti-infection treatment can be given, such as using sensitive antibiotic ceftriaxone. 2. Lung cancer: Cancer cells can invade the pleura through blood circulation, lymph nodes or directly, resulting in patients with multiple subpleural nodules. If the condition permits, lung resection is feasible, and radiotherapy, such as cisplatin and other chemotherapeutic drugs, should be used as appropriate. 3. Malignant tumors of pleura: malignant tumors of pleura will be disseminated and spread, which will easily lead to the symptoms of subpleural multiple nodules, feasible surgical resection, postoperative chemotherapy, radiotherapy and other comprehensive treatment, chemotherapeutic drugs, such as paclitaxel and so on. Subpleural multiple nodules can also be seen in other diseases, it is recommended that patients go to a regular hospital in time to listen to the advice of a professional doctor.