The clinical approach to melanin transplantation is mainly negative pressure suction blister epidermal transplantation as well as bladed thick skin slice transplantation, which mainly treats hypopigmented diseases such as vitiligo and anaplastic nevi.1. Negative pressure suction: take blisters in a wide part of the skin, usually in the abdomen or thigh area. When blistering after using sterile scissors to cut down the blister, grind the white spot to the state of punctate bleeding, apply the wall of the blister to the white spot, and then apply pressure bandage. The second, the edge of the thick skin piece transplantation: is the use of special instruments to take the material, the location of the material is not restricted, mainly to take the complete epidermis layer and a small amount of dermis, and then transplanted to the white spots. Compared with the first melanin transplantation method, the thick skin graft is easy to survive, not easy to be infected, and the pigmentation of the recipient area is evenly distributed, but of course, the cost is also more expensive than the first one.