Hepatitis B 135 to 15 indicates that the E antigen has turned negative, and the patient has changed from hepatitis B major triple Yang to hepatitis B minor double Yang, indicating that hepatitis B is less infectious and the virus replication ability is weakened. Hepatitis B five are hepatitis B surface antigen, surface antibody, E antigen, E antibody, core antibody, hepatitis B 135 refers to the first hepatitis B surface antigen, E antigen, core antibody is positive, known as triple sun, infectious, rapid viral replication. Hepatitis B 15 means that the surface antigen and core antibody of hepatitis B are positive, which is known as small bi-yang. Hepatitis B 135 to 15 means that the third E antigen has turned negative, indicating that the immunity in the body has been strengthened, the replication of the virus has been suppressed, and it may be in the process of clearing the virus, and the contagiousness has been reduced at this moment. Patients should continue to follow the doctor’s instructions to receive treatment, and consult a doctor when there is a change in their physical condition.