You can take tadalafil after drinking alcohol. Tadalafil is a new PDE5 inhibitor for erectile dysfunction, which is called Viagra by the people, and Viagra is a class of drugs. Viagra is a short-acting preparation, while tadalafil is a long-acting preparation that can last for 36 hours. The advantage is that the onset of action is long, up to 36 hours, and is not affected by diet, especially a high-fat diet, nor by alcohol consumption. Therefore, theoretically it is possible to take tadalafil and drink alcohol, but in practice drinking alcohol is not good for sexual erection, and excessive drinking can inhibit erection, so it is better not to drink alcohol.