You can take omeprazole after drinking alcohol. Omeprazole is a drug that is commonly used clinically to inhibit gastric acid secretion and protect the gastric mucosa, which is very effective for chronic gastritis and gastric ulcer. After drinking a lot of alcohol, it is also easy to cause serious complications such as perforation of the digestive tract or bleeding. After taking the drug, you need to observe the symptoms of the abdomen, such as whether there is an increase in abdominal pain, dark stools and other changes. If any of these changes occur, you must go to the hospital in a timely manner, improve the relevant tests, assess whether there is gastrointestinal bleeding, timely hospitalization and infusion treatment, and also pay attention not to drink a lot of alcohol in general.