When patients have generalized wandering pain, most of them are caused by rheumatoid diseases, generally because rheumatoid diseases invade various joints, and the onset time at each joint is different, which will cause patients to have generalized wandering pain. It is recommended that patients should go to the hospital for relevant examinations, such as blood sampling, laboratory tests, rheumatology complete set, which can clarify the diagnosis. In case of localized joint pain, X-rays of the joints can be performed, which can also help clarify the diagnosis. It is recommended that patients must actively treat the symptoms and keep the joints warm to effectively avoid the onset of rheumatoid arthritis. If the pain is obvious, it is recommended to take oral ibuprofen extended-release capsules or indomethacin enteric-coated tablets, which can effectively control the symptoms of pain. It is also possible that the pain may be caused by a viral infection, and patients should be advised to go to the hospital for relevant tests to clarify the diagnosis. When the virus in the body is controlled, the wandering pain symptoms can also be effectively relieved.