Reflux esophagitis can cause shoulder pain and other uncomfortable symptoms. Reflux esophagitis is an inflammatory lesion of the esophagus caused by the reflux of gastric and duodenal contents into the esophagus, which endoscopically manifests as a breakdown of the esophageal mucosa, i.e., esophageal erosions and/or esophageal ulcers. When refluxed food triggers inflammatory pain in the esophagus, it occurs in the back with radiating pain that manifests as a painful sensation in the shoulders and back. When suffering from reflux esophagitis, it is recommended to take medications to protect the gastric mucosa (e.g., omeprazole, etc.) and medications to promote gastric motility (e.g., mosapride, etc.) under the guidance of a doctor. In daily life, appropriate intake of vitamin-rich vegetables and fruits, avoid spicy, greasy and other stimulating foods. It should be noted that shoulder pain may also be caused by other diseases, such as frozen shoulder, tendon strain, etc. It is recommended to consult a doctor in time to clarify the cause of the disease under the guidance of a professional physician and carry out treatment to avoid aggravating the condition.