The clinical manifestations of intracerebral parenchymal metastasis and meningeal metastasis of lung cancer have their commonalities and characteristics. The clinical manifestations of brain parenchymal metastases include common intracranial pressure increase and specific focal symptoms and signs. The symptoms and signs of increased intracranial pressure are mainly headache, vomiting and optic nerve papilledema. In addition to these three main signs, diplopia, dark haze, decreased visual acuity, dizziness, apathy, impaired consciousness, diaphoresis, bradycardia and increased blood pressure may also be present. Symptoms often worsen progressively, and symptoms of acute intracranial pressure increase may occur in cases of cystic metastases or intratumoral strokes. Focal symptoms and rest signs of metastases near the functional areas of the cerebral hemispheres may show local irritation symptoms in the early stage and neurological destructive symptoms in the late stage, and tumors in different sites may produce different localized symptoms and signs, including Seizures: frontal lobe tumors are more common, followed by temporal lobe and parietal lobe tumors. It can be generalized clonic grand mal seizure or limited seizure. 3.Sensory impairment: It is a common symptom of parietal lobe metastases, manifesting as two-point discrimination, solid perception and position perception of the contralateral limb. 4.Motor disorders: manifested as tumor contralateral limb or muscle weakness or complete upper motor neuron paresis. 5.Aphasia: It is seen in metastases in the language center area of the dominant cerebral hemisphere, which may manifest as motor aphasia, sensory aphasia, mixed aphasia and naming aphasia. 6. Visual field damage: deep tumors in occipital and parietal lobes and temporal lobes may cause contralateral isotropic visual field defects or contralateral isotropic hemianopia due to the involvement of visual radiation. Thalamic metastases can produce thalamic syndrome, which mainly manifests as: contralateral sensory deficit and/or stimulation symptoms, contralateral involuntary movements, and may have emotional and memory impairment. Clinical manifestations of cerebellar metastases: 1. Cerebellar hemisphere tumor: blast speech, nystagmus, impaired coordinated movements of the affected limb, ipsilateral hypotonia, blunted tendon reflexes, easy to lean to the affected side, etc. 2.Tumor of cerebellar earthworm: mainly manifests as unstable gait, difficulty in walking, leaning backward when standing. 3.Tumor obstruction: hydrocephalus and increased intracranial pressure appear in the early stage of the fourth ventricle. Most of the brain stem metastases show crossed paralysis, i.e. peripheral paralysis of brain nerve on the side of the lesion and central paralysis and sensory disorder of the opposite limb. The location of the metastases can be localized according to the damaged brain nerves: if the third pair of cerebral nerves is paralyzed, the tumor is located in the midbrain. If V, VI, VII, VIII pairs of cerebral nerve palsy, the tumor is located in the cerebral bridge. If the nerve is paralyzed in pairs IX, X, XI, and XII, the tumor invades the medulla oblongata. The clinical manifestations of patients with meningeal metastases are often complex and varied depending on the site of tumor cell invasion, and lack specificity. Some patients are diagnosed with meningeal metastasis because of progressive worsening of neck and shoulder pain. The main clinical manifestations of meningeal metastases include: brain parenchymal involvement and meningeal irritation: headache, vomiting, cervical tonicity, meningeal irritation signs, mental status changes, hazy consciousness, cognitive impairment, seizures and physical movement disorders. Cranial nerve involvement manifestations: Commonly involved brain nerves include optic nerve, actinic nerve, gliding nerve, abducens nerve, facial nerve and auditory nerve, which manifest as decreased visual acuity, diplopia, facial numbness, abnormal taste and hearing, difficulty in swallowing and pronunciation, etc. Increased intracranial pressure manifests as: headache, vomiting, optic papillary edema and progressive cerebral dysfunction manifested by hydrocephalus compression of brain tissue: mental retardation, walking impairment, urinary incontinence, etc. Spinal cord and spinal nerve root irritation may also be present if there is concomitant spinal dissemination. These also help in the diagnosis of meningeal metastases, such as neurogenic pain, segmental sensory deficits, limb numbness, sensory ataxia, diminished or absent tendon reflexes, and sphincter dysfunction.