Multiple myeloma is a malignant bone marrow tumor in which the tumor cells originate from plasma cells. The disease is more common in middle-aged and elderly people, and there are more males than females. Clinical manifestations include chronic bone pain and discomfort, anemia, infection, renal insufficiency, hepatosplenomegaly, hypercalcemia, and neurological symptoms. Blood biochemistry, blood series, bone marrow examination and bone imaging examination are indispensable, among which PET-CT examination is the most sensitive, followed by MR. Early stage of multiple myeloma may only show back pain and anemia.1. Go to the hematology department of the hospital for blood and bone marrow examination, and imaging examination if necessary.2. Tissue and organ damages (including bone damages, renal function damages, elevated blood calcium, etc.) need to be treated. Treatment mainly includes: (1) general treatment, including correction of anemia, lowering calcium, anti-infection, kidney dialysis, etc. (2) Chemotherapy, immunosuppressant targeting and systemic therapy. (3) Hematopoietic stem cell transplantation. 3. Those without tissue or organ damage do not need special treatment for the time being, but they need to go to the hospital regularly for review and closely observe their condition.