The treatment of advanced multiple myeloma depends on: 1, whether the patient’s physical condition is good or weak, good or weak determines the intensity of the treatment of advanced multiple myeloma. 2, look at the previous treatment program for multiple myeloma, especially the program adopted about one year before relapse and progression, which determines the choice of the subsequent treatment program. Total multiple myeloma current main therapeutic drugs have the following three kinds: 1, proteasome inhibitors such as bortezomib, carfilzomib. 2, immunomodulators such as thalidomide, lenalidomide, and pomalidomide in foreign countries. 3, the so-called monoclonal antibody drugs such as CD38 monoclonal antibody is also known as DARA. these drugs can be and dexamethasone combination together, composed of different programs, the specific how to combine is The earlier mentioned depends on what kind of treatment program has been used for about one year before the relapse and progression.