Neurosis, also known as somatization disorder, is a type of neurosis. It has proven to be difficult to cure. The onset of the disease may be related to the patient’s personality, with cautiousness, pursuit of perfection, psychological fragility, more concerned about the self, and less ability to bear pain. The main clinical manifestations are various somatic discomforts, such as chest tightness, panic, gastrointestinal discomfort, indigestion, etc. No obvious diseases are detected after various examinations or the detected diseases cannot explain the patient’s symptoms. Doctors still can’t accept it after various explanations, and still think they are sick, thus seeking for medical treatment around. Treatment is mainly psychotherapy, combined with anti-anxiety and anti-depressant drugs, such as buspirone, escitalopram, duloxetine, etc. Psychotherapy is mainly family therapy, cognitive therapy, and some patients will improve their symptoms after systematic treatment.