Recurrent fever in lymphadenitis is caused by internal and external pyrogens produced by the inflammation, which reach the thermoregulatory centers through the blood circulation and stimulate them. Lymphadenitis can produce internal and external pyrogens. The former includes the bacteria that cause lymphadenitis, gram-positive bacteria such as Gram-positive bacteria such as Staphylococcus aureus and gram-negative bacteria such as Escherichia coli. Exotoxins released by positive bacteria and endotoxins produced by the cell walls of negative bacteria can cause fever. Inflammation can cause leukocyte pyrogens such as interleukins and other substances to reach the thermoregulatory center, causing a change in the thermoregulatory point. Repeated fever for inflammation is not completely cured, inflammatory mediators repeatedly act on the thermoregulatory center, positive regulatory mediators such as prostaglandin E, cyclic adenosine monophosphate, etc., and negative regulatory mediators such as arginine pressor, etc., interaction, the end result determines that the body temperature rises. Recurrent fever with lymph node inflammation requires medical attention to avoid exacerbating the condition.