Salicylic acid poisoning is usually caused by a single overdose or prolonged application, especially in infancy when accidental overdose can easily occur. In addition, topical salicylic acid ointment can also be absorbed through the skin if it is applied to a large area of broken skin, leading to poisoning. After poisoning, firstly, 5% sodium bicarbonate should be used to wash the stomach, and then about 50g of medical activated charcoal should be given by gavage every 4 hours for 24 hours. Secondly, active diarrhea should be conducted, and a large amount of oral sodium bicarbonate should be given to raise the pH of gastric juice to reduce the absorption of the drug. At the same time, rapid rehydration, saline and glucose solution to prevent the occurrence of hypovolemic shock, can also be adjusted according to the amount of urine infusion. For more serious symptoms, due to the high plasma protein binding rate of salicylic acid, blood perfusion or plasma exchange can be applied to detoxification, but also to give the body acid-base balance and metabolic disorders and other aspects of the treatment.