Three years after surgery for hypertrophic cardiomyopathy, a recurrence can be eliminated through medication, interventional therapy, and daily care. Recurrence of hypertrophic cardiomyopathy is a relatively common condition, so it should not be taken lightly after surgery. In patients with recurrence, propranolol hydrochloride and diltiazem can usually be used to reduce left ventricular outflow tract obstruction when symptoms are mild. It can also be combined with hydrochlorothiazide, irbesartan, and amiodarone to provide relief if heart failure or atrial fibrillation is present. If medication cannot achieve the desired effect and it is obstructive hypertrophic cardiomyopathy, alcohol septal ablation can be used to infarct the myocardium in the hypertrophic area, resulting in the effect of thinning the base of the septum. In daily life, patients should learn to self-regulate their emotions, do not be too nervous and fearful. In addition, they should not participate in strenuous exercise and should go to the hospital for regular checkups. The prognosis of hypertrophic cardiomyopathy varies greatly, and most patients with mild disease can effectively control their disease. However, atrial fibrillation, heart failure, embolism and other adverse conditions may occur, so we should be vigilant and scientific treatment. Specific diagnosis and treatment should follow the doctor’s instructions.