Clinical manifestations of pituitary tumor mainly include tumor-occupying manifestations (headache, visual field disorder) and endocrine manifestations (amenorrhea, lactation, sexual dysfunction, acromegaly, Cushing’s appearance, etc.). 1. Tumor occupying manifestations. (1) Headache: pituitary adenoma will cause increased pressure in the saddle and pressure on the saddle diaphragm, causing headache, which is mostly located in the two temporal sides, forehead and the back of the eyes. In the late stage, headache is often caused by the development of the tumor to the parasympathetic saddle, compression of the trigeminal nerve or cerebrospinal fluid circulation disorders, resulting in increased intracranial pressure. (2) Visual acuity and visual field disorders: mostly due to the upward development of the tumor breaking through the saddle diaphragm and compressing the optic nerve, optic nerve, optic cross or optic tract. The most common is bilateral temporal hemianopsia. 2. Endocrine manifestations. (1) Tumor cells over-secrete prolactin, causing hyperprolactinemia, which manifests as amenorrhea, breast overflow and infertility in women. In male patients, it may manifest as decreased libido, impotence, genital atrophy or infertility due to decreased spermatozoa. (2) Over secretion of growth hormone by tumor cells. It is mainly overgrowth of bones, soft tissues and internal organs. In prepubertal adolescent patients, it manifests as gigantism, and in adults, it manifests as acromegaly. (3) Blood cortisolism caused by over-secretion of ACTH by tumor cells. Clinical manifestations are overweight, centripetal obesity, full-moon face, buffalo back, sagging accumulation of abdominal fat, atherosclerosis, capillary dilatation, polycythemia of the face, subcutaneous blood vessels in the lower abdomen are revealed, and skin stretch marks appear. Pituitary tumor belongs to the common disease of neurosurgery, which needs timely consultation and treatment.