[Abstract] OBJECTIVE: To observe the effect of local injection of botulinum toxin type A (BTX-A) in neurological diseases. Methods: In 258 cases of HFS, 158 cases of limited dystonia (31 cases of Meige syndrome, 56 cases of BS, 64 cases of ST and 7 cases of WC) and 9 cases of spasticity state, BTX-A was injected by local intramuscular multi-point injection, and the efficacy was analyzed and evaluated by following up for more than six months. Results: HFS, 99.2% effective rate; BS, 96.4% effective rate; Meige syndrome, 83.9% effective rate; ST, 85.9% effective rate; WC, 42.9% effective rate; spasticity, 66.7% effective rate. The effective duration of action was 10-20 weeks (mean 13.2 weeks). There were no systemic toxic symptoms and allergic reactions, and the local side effects were mild, transient and reversible. CONCLUSION: BTX-A local injection is a safe, effective, simple and easy to use treatment, and can be used as the drug of choice for lateral spasticity and limited dystonia.