1. How can Paget’s disease of the breast be differentiated from eczema in terms of symptoms? The symptoms of nipple Paget’s disease include erythema, desquamation, vesicles, rupture, repeated crusting to produce granulation, and disappearance of the nipple. Paget’s disease is often overlooked because of the itchy, burning sensation of the nipples. The papillary eczema is well-defined, with brownish-red lesions and visible vesicles covered with scales or thin crusts. Patients feel itchy and painful. 2.What is the difference between Paget’s disease of the breast and the site of eczema? Paget’s disease of the nipple is usually found on the nipple and areola, and in some early stage patients it occurs at the opening of the milk ducts of the nipple. Breast eczema can occur anywhere on the breast, but is commonly found around the nipple or in the lower part of the breast. 3. If diagnosed with nipple eczema, what are the conditions that should alert you that it is actually Paget’s disease of the breast? If diagnosed with nipple eczema, eczema is not effective after treatment. Show a slow course of the disease, and does not heal over time. At this time, should be alert to paget’s disease. 4, eczema patients suspected of breast Paget’s disease, what tests should be done for diagnosis? Local skin exfoliation cell examination, radiographic examination, scraping part of the lesion skin tissue examination can help diagnose. An excisional biopsy can provide a conclusive diagnosis. Breast Paget’s disease should be diagnosed by mammography, ultrasonography, or MRI to rule out the possibility of ductal carcinoma of the breast. 5.What other diseases should Paget’s disease of the breast be differentiated from? Breast Paget’s disease should also be differentiated from nodular cutaneous amyloidosis, Bowen Disease, contact dermatitis, drug rash, malignant melanoma, etc.