There are many causes of calf muscle pain, such as trauma, infection, strain, nerve and blood vessel related diseases, we need to identify the cause of the disease, and then give the relevant treatment for the cause, such as general treatment, physical therapy, drug treatment and surgical treatment. 1. Trauma: In the acute stage, cold compresses should be applied locally to relieve pain and reduce edema, and hot compresses should be applied locally in the relieving stage to promote local blood circulation and help recovery. For severe pain, painkillers such as ibuprofen can be given. For the existence of serious muscle cracks need to be given to surgical repair. 2. Infection: mildly give cephalosporin, ofloxacin and other antibacterial drugs anti-infection treatment, serious infection abscess formation, need to give surgical incision and drainage. 3. Strain: it can be caused by excessive accumulation of lactic acid in the calf muscle, which can be recovered by itself, and local massage and hot compresses can be used to promote absorption if necessary, and painkillers such as diclofenac sodium can be given for obvious pain. 4. Neurological diseases: common lumbar spine diseases such as lumbar disc herniation and sciatica caused by pyriformis syndrome, etc., need to be treated for the primary disease, give methylcobalamin and other nutritive nerve drugs, and if necessary, give radiofrequency ablation, adhesion laxation and other surgical treatments. 5. Vascular disease: common thrombophlebitis, need to elevate the affected limbs, local hot compresses, etc., severe pain can be given to ibuprofen and other painkillers, deep vein thrombosis need to be given to low molecular heparin sodium anticoagulant therapy, serious cases need to be surgically extracted from the thrombus treatment. It is recommended that the patient go to the hospital, improve the auxiliary examination, to clarify the cause of the disease, drugs need to be used under the guidance of a professional physician.