Ear pain in myelodysplastic syndrome is considered to be related to infection and cerumen blockage, etc. Treatment such as anti-infection and cerumen removal should be carried out. 1. Myelodysplastic syndromes often cause leukopenia and can reduce the body’s immunity, making it easy to secondary infections in various systems. If the outer ear canal is injured when pulling out the ear normally, it can cause ear canal infection, in which case it should be treated with anti-infection ear drops, such as levofloxacin ear drops. If the earache is more serious, oral macrolides (e.g. azithromycin) can be taken. 2. If the external auditory canal is blocked by cerumen, especially after the ear has been filled with water, the ear will be painful due to the presence of a foreign body, at this time, it is necessary to consult a doctor in a timely manner to clean the cerumen and clear the external auditory canal. Ear pain in myelodysplastic syndrome may also be related to other causes. When symptoms occur, you should seek immediate medical attention to identify the cause and standardize the treatment under the guidance of your doctor. The above medications should also be used under medical supervision.