Positive urine weekly protein in most cases suggests the presence of multiple myeloma. Multiple myeloma is a disease that produces a lot of immunoglobulins and certain components of immunoglobulins, such as light chains, which are reabsorbed by the tubules after glomerular filtration. If there is a particularly large amount of immunoglobulin produced, which exceeds the reabsorption capacity of the tubules, it can be detected in the urine, and this is known as a positive periplasmic urine protein. It can be seen from here that urine peripheral protein is one of the components of immunoglobulin. If urine periplasmic protein is found to be positive in the clinic, the diagnosis of multiple myeloma cannot be fully confirmed, and bone marrow aspiration examination is needed to further clarify the diagnosis. The prognosis of multiple myeloma is not very good, and the survival time is relatively short. In addition to positive urine peripheral protein, this disease can also cause acute renal failure.