Acute pyelonephritis is generally applied quinolone antibiotics and cephalosporin antibiotics are more effective, the following specific analysis: Acute pyelonephritis is a kind of urinary tract infection, most of them are caused by bacterial infections, and its symptoms include frequent urination, urgency of urination, painful urination, lumbar pain, fever and so on. Its treatment is usually to give urine culture and drug sensitivity test first, according to the culture results to clarify the causative bacterial species and choose the appropriate antibiotics. The more effective antibiotics are quinolone antibiotics and cephalosporin antibiotics, quinolone antibiotics commonly used are levofloxacin, ciprofloxacin, etc., and cephalosporin antibiotics are commonly used are cefoperazone sodium sulphadiazine sodium, ceftriaxone sodium, etc. Acute pyelonephritis has a good prognosis after the above medication and can be cured in general.