Children with fever have hot hands but cold feet because of the increase in body heat production leading to hot hands, decrease in heat dissipation and poor blood circulation in the feet leading to cold feet. When a child has a fever, fever-activating agents such as bacteria and viruses stimulate the body to produce endogenous pyrogens, which act on the thermoregulatory center and cause the thermoregulation point to shift upward, resulting in the initial body temperature being lower than the thermoregulation point. In order to raise the body temperature to the level of the thermoregulation point, the body will increase heat production, resulting in an increase in body temperature, which is manifested in the fever of children with hot hands. At the same time, the body will also reduce heat loss by contracting the skin capillaries and reducing capillary blood flow. As a result, the child’s peripheral circulation slows down at this time, and the feet are farther away from the heart, so in the stage of rising body temperature will appear cold feet. Children with fever and hot hands but cold feet, there may be other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.