Bile leak after cholecystectomy is one of the complications after cholecystectomy. MRCP examination cannot determine the site of bile leak, and blind open surgery may bring more harm to the patient or even endanger his life. In recent years, 6 cases of bile leak were treated by endoscopy in our department, 5 cases were cured and 1 case was ineffective. In 6 patients with biliary leakage after cholecystectomy, the perforated abdominal tube was placed to drain under the guidance of B ultrasound, and the drainage flow was 300-800ml per day. ERCP examination found that the leakage was in the stump of the cystic duct in 4 cases, the lateral wall of the upper part of the common bile duct in 1 case, and no contrast spillage was seen in 1 case, and all of them were given nasobiliary drainage, and the bile flow from the abdominal drainage tube decreased significantly in 5 patients on the 2nd postoperative day, which was only 100-150ml, and the patients The abdominal pain was significantly reduced, and 3 days later there was no fluid in the abdominal drainage tube, two weeks of nasobiliary cholangiography, no contrast overflow was found, the next day the tube was removed, and the patient was discharged cured; the one case where no contrast overflow was seen was ineffective, and no reduction in abdominal drainage was seen, which was considered to be a proximal bile duct leak, not connected to the common bile duct, and surgical treatment was changed. Endoscopic treatment of biliary leaks requires only routine pharyngeal anesthesia, with little physiological interference and short preoperative preparation time. The site of bile leak can be identified during ERCP examination, and the endoscopic treatment is effective and quick. Patients with biliary leakage are generally weak and are particularly suitable for minimally invasive treatment with little trauma, avoiding the problems of excessive abdominal harassment and restenosis after bile duct scar formation brought about by open surgery. All five patients treated effectively in our department were hospitalized within 20 days. Compared with open surgery, endoscopic treatment has the advantage of significantly shortening the treatment time and reducing the occurrence of reoperative complications. However, endoscopic treatment may not be useful in those with complete transection injuries of the common bile duct. Minimally invasive endoscopic examination and treatment is preferred for biliary leakage after cholecystectomy!